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Bacterial Resistance to Antimicrobials - 2nd edition

Edited by Kim Lewis, Abigail A. Salyers, Harry W Taber and Richard G Wax 
Marcel Dekker  May 2007  



Hardcover  448 pages, Illustrated  ISBN 9780849391903      £127.00
  • Provides comprehensive coverage of various forms of antibiotic resistance and the transfer of these mechanisms
  • Presents the most current advances in the field of antibiotic resistance
  • Discusses a global approach to containment
  • Features new strategies for the development of antibiotics

The enormous genetic flexibility of bacteria jeopardizes the usefulness of currently available antibiotics, and requires new approaches to antibiotic discovery and development. Antimicrobial resistance can be acquired in a short time frame, both by genetic mutation and by direct transfer of resistance genes across genus and species boundaries. Understanding mechanisms of resistance is crucial to the future of antimicrobial therapy.

The second edition is extensively revised, with contributions from international leaders in their fields, Bacterial Resistance to Antimicrobials, Second Edition blends scientific and practical approaches to the social, economic, and medical issues related to this growing problem. The book begins with a history of antimicrobial agents and bacterial resistance, and outlines the forces that contributed to the abuse of antibiotics and precipitated the current crisis. It goes on to describe what is known about the ecology of antibiotic resistant bacteria and reveals the inadequacies in our understanding. Emphasizing public health aspects, the editors stress that significant progress will be made only by addressing the problem only as a public, worldwide, problem.

Chapters on resistance mechanisms describe the latest findings on what makes different groups of bacteria susceptible or resistant to antibiotics. They reveal the staggering diversity of bacteria and the need for a foundational understanding that will stimulate development of antibiotics capable of avoiding resistance mechanisms. Examining the success and limitations of complementary approaches, such as combining -lactam antibiotics with -lactamase inhibitors, the book brings together information on resistance mechanisms in different groups of bacteria to help future efforts to more effectively develop and deploy antimicrobial therapies.

Contents

  • Microbial Drug Resistance: A Historical Perspective, W.C. Summers
  • Ecology of Antibiotic Resistance Genes, A.A. Salyers, N. Shoemaker, and D. Schlesinger
  • Global Response Systems that Confer Resistance, P.F. Miller and P.N. Rather
  • Multidrug Efflux Pumps: Structure, Efflux, and Inhibition, O. Lomovskaya, H.I. Zgurskaya, K.A. Bostian, and Kim Lewis
  • Mechanisms of Aminoglycoside Antibiotic Resistance, G.D. Wright
  • Resistance to -Lactam Antibiotics Mediated by -Lactamases, J.Y. Cha, L.P. Kotra, and S. Mobashery
  • Target Modification as a Mechanism of Antimicrobial Resistance, D.C. Hooper
  • Antibiotic Permeability, H. Taber
  • Genetic Methods for Detecting Bacterial Resistance Genes, A.C. Fluit
  • The Evolution and Epidemiology of Antibiotic Resistant Pneumococci, C.G. Dowson and K. Trzcinski
  • Antimicrobial Resistance in the Enterococcus, G.M. Eliopoulos
  • Methicillin Resistance in Staphylococcus aureus, K.S. Gilmore and M.S. Gilmore
  • Mechanism of Drug Resistance in Mycobacterium tuberculosis, A.S. Pym and S.T. Cole
  • Antibiotic Resistance in Enterobacteria, N.H Georgopapadakou
  • Resistance as a Worldwide Problem, P. Shears
  • Public Health Responses to Antimicrobial Resistance in Outpatient and Inpatient Settings, C.R Friedman and A. Srinivasan
  • Antibacterial Drug Discovery in the 21st Century, S.J. Projan
To find similar publications, click on a keyword below:
Marcel Dekker : antibiotics : bacteriology : biomedical sciences : chemistry : disease control : health & beauty : microbiology : pharmaceuticals : virology

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