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Fungal Pathogenesis - Principles and Clinical Applications

Edited by Richard A Calderone and Ronald L Cihlar 
Marcel Dekker  October 2001  



Hardcover  776 pages, Illustrated  ISBN 9780824705688      £164.00
Stresses molecular and biochemical studies of opportunistic and frank fungal pathogens!

This book gives a comprehensive overview of human pathogenic fungi that offers a current and concise survey of virulence factors, host responses and recognition, treatment and diagnosis of infections, invasive enzymes, intracellular survival, morphogenesis, adaptation, and properties of major fungal pathogens that contribute to disease.

Focuses on human fungal infections, including candidiasis, pneumocystosis, aspergillosis, and cryptococcosis.

With over 3700 references to accommodate continuing study, Fungal Pathogenesis

  • covers natural and acquired immunity, vaccine development, and immune reconstitution
  • outlines rapid identification of major mycoses utilizing antigen capture and molecular assays
  • details signaling and phenotypic switching
  • discusses the value of genomics in validation
  • highlights state-of-the-art molecular methodologies to study disease-causing organisms
  • describes available and potential antifungal drug targets and drug development
  • considers predicting the consequences of drug resistance on patient management
  • presents topical observations on strain typing and variation
Containing research into the virulence, immunity, diagnosis, and therapy of most common fungal infections, Fungal Pathogenesis is an unparalleled reference for microbiologists, virologists, pathologists and phytopathologists, infectious disease specialists, molecular and cell biologists, biochemists, immunologists, medical mycologists, biotechnologists, and geneticists, and an exceptional text for upper-level undergraduate, graduate, and medical school students in these disciplines.

Contents

Genetic Basis of Pathogenicity in Cryptococcus neoformans, Brian L. Wickes and K. J. Kwon-Chung
Secretory Proteins in Fungal Virulence, Pranab K. Mukherjee and Mahmoud A. Ghannoum
Histoplasma capsulatum: Diary of an Intracellular Survivor, Simon L. Newman
Dimorphism in Human Pathogens, Jon P. Woods
Signaling and the Biology of Human Fungal Pathogens, Jose Antonio Calera and Richard A. Calderone
Adaptation of Fungi to Alterations in Ambient pH, Oliver Kurzai, Abdelmalic El Barkani, and Fritz A. Mühlschlegel
Molecular Biology of Switching in Candida, David R. Soll
Pathogenic Properties of Blastomyces dermatitidis, Bruce S. Klein and Wun-Ling Chang
Paracoccidioides brasiliensis: Virulence and Host Response, Gioconda San-Blas and Gustavo Niño-Vega
Pneumocystis carinii, Henry Koziel
Genomics in Fungal Pathogenesis, Janna L. Beckerman and P. T. Magee

HOST RESPONSES TO PATHOGENIC FUNGI/IMMUNOPROTECTION
Cell-Mediated Immunity and Endemic Mycoses, D. Mitchell Magee and Rebecca A. Cox
Humoral Immunity and Cryptococcus neoformans, Arturo Casadevall
Vaccines, Antibodies, and Passive Immunity in Candidiasis, Jim E. Cutler, Bruce L. Granger, and Yongmoon Han Vaccines for Histoplasmosis, George S. Deepe, Jr.
Coccidioidomycosis: Pathogenesis, Immune Response, and Vaccine Developmen, Theo N. Kirkland and Garry T. Cole
Innate Immunity Against Fungal Pathogens, Luigina Romani
Immune Reconstitution Against Human Mycoses, Emmanuel Roilides, Evangelia Farmaki, and Caron A. Lyman
Mucosal Infection and Immunity in Candidiasis, Flavia De Bernardis and Maria Boccanera
Systemic Immunity in Candidiasis, Luigina Romani and Francesco Bistoni
Cell Wall of Aspergillus fumigatus: Structure, Biosynthesis, and Role in Host-Fungus Interactions, Isabelle Mouyna and Jean-Paul Latgé
Cryptococcus neoformans and Macrophages, Thomas S. Harrison and Stuart M. Levitz

TREATMENT AND PATIENT MANAGEMENT
Antifungals Currently Used in the Treatment of Invasive Fungal Diseases, Xiao-jiong Zhao and Richard A. Calderone
Antifungal Drug Targets: Discovery and Selection, Ronald L. Cihlar, Sheldon Broedel, Jr., and Christina Kellogg
Drug Resistance Mechanisms of Human Pathogenic Fungi, Rajendra Prasad, Sneh Lata Panwar, and Shankarling Krishnamurthy
Antifungal Susceptibility Testing: Clinical Interpretations and Utility, Sofia Perea and Thomas F. Patterson

THE DIAGNOSTIC LABORATORY
Molecular Diagnosis of Fungal Infections, Roy L. Hopfer and Darius Amjadi
Serological Approaches to the Diagnosis of Invasive Fungal Infections, Christine J. Morrison and Mark D. Lindsley
Molecular Typing and Epidemiology of Candida spp. and Other Important Human Fungal Pathogens, Derek J. Sullivan and David C. Coleman
Strain Variation and Clonality in Candida spp. and Cryptococcus neoformans, Jianping Xu and Thomas G. Mitchell
New and Emerging Pathogens: What's a Lab to Do? Chester R. Cooper, Jr.

Index

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Autumn 2001 : Marcel Dekker : biomedical sciences : biotechnology : cell biology : enzymology : genetics : immunology : microbiology : molecular biology : mycology : plant pathology : virology

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