Glycoscience - Chemistry and Chemical Biology - second edition
Edited by Fraser-Reid, B.O.; Tatsuta, K.; Thiem, J.; Coté, G.L.; Flitsch, S.; Ito, Y.; Kondo, H.; Nishimura, S.-I.; Yu, B.
Hardcover 2875 pp - in 3 vols. ISBN 9783540361541
- Completely revised and updated to reflect the "quantum jump" in the field of glycostructures
- Three new chapters on: Key Technology and Tools, Biosynthesis and Glycomedicine
- Includes more than 12,000 chemical reactions and more than 9,000 references
Here is another of Springer's Major Reference Works, an utterly essential resource for scientists in a
huge range of disciplines. This one covers the key area of Glycoscience, a rapidly evolving field with
applications across the spectrum.
As a reflection of the quantum leap that has been made in the study of glycostructures, the first edition
of this book has been completely revised and updated.
The editors provide up-to-date information on glycostructures, their chemistry and chemical biology in the form
of a completely comprehensive survey.
The texts are illustrated by more than 2500 figures, chemical structures and reaction schemes (including more than
12,000 individual chemical reactions), and more than 9,000 references.
Glycostructures play highly diverse and crucial roles in a myriad of organisms and important systems in biology,
physiology, medicine, bioengineering and technology.
Only in recent years have the tools been developed to partly understand the highly complex functions and the
chemistry behind them.
While many facts remain undiscovered, this MRW has been contributed to by a large number of the world€s
leading researchers in the field, and thus constitutes the very latest information on this exciting topic.
Written for chemists, biochemists, pharmacists, and medical researchers in pharmaceutical and chemical
industry; researchers and engineers in food technology and agrobusiness; researchers in organic, medicinal and
biochemistry and in molecular medicine.
1 General Principles
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1.1 Structure and Conformation of Carbohydrates.- 1.2 General Occurance and Properties of
2 General Synthetic Methods.
2.1 Reactions at Oxygen Atoms.- 2.2 Oxidation, Reduction and Deoxygenation.- 2.3 Heteroatom Exchange.-
2.4 Anhydrosugars.- 2.5 C-C Bond Formation.- 2.6 C=C Bond Formation.- 2.7 Degradations and Rearrangement
3 Chemical Glycosylation Reactions
3.1 Introduction to Glycosylation Reactions.- 3.2 Glycosyl Halides.- 3.3 Glycosyl Trichloroacid Imidates.-
3.4 Other Anomeric Esters.- 3.5 O-Glycosyl Donors.- 3.6 S-Glycosylation.- 3.7 Glycal Derivatives.-
3.8 Anomeric Anhydro Sugars.- 3.9 C-Glycosylation.
4.1 Occurance, Significance and Properties.- 4.2 Monosaccharides and Polyols in Foods.-
4.3 De Novo Synthesis of Monosaccharides.- 4.4 Monosaccharides as Chiral Pools for the Synthesis
of Complex Natural Compounds.- 4.5 Monosaccharides as Scaffolds for the Synthesis of Novel
Compounds.- 4.6 Monosaccharides as Chiral Auxiliaries and Ligands for Asymmetric Synthesis.-
4.7 Carbohydrate Metal Complexes.
5.1 Occurrence, Significance and Properties.- 5.2 Sucrose and Related Oligosaccharides.-
5.3 Oligosaccharides in Food and Agriculture.- 5.4 Combinatorial Methods in Oligosaccharide Synthesis.-
5.5 Solid Phase Methods.- 5.6 Stereoselective Synthesis of ß-Manno Glycoside.- 5.7 Silalylation.-
5.8 Enzymatic Glycosylation by Tranferases.- 5.9 Enzymatic Glycosylation by Hydrolases
6 Complex Polysaccharides.
6.1 Occurence, Significance and Properties.- 6.2 Starch.- 6.3 Cellulose and Hemicellulose.-
6.4 Gums and Related Polysaccharides.- 6.5 Bacterial Cell Wall Components.- 6.6 Fungal Cell
Wall Components.- 6.7 Structure-Activity Relationship of Glycosaminoglycans
7.1 Occurence, Significance and Properties.- 7.2 Synthesis.- 7.3 Biosynthesis and Degradation.-
8.1 Occurence and Significance.- 8.2 Properties.- 8.3 Synthesis and Applications of Biologically
Relevant Glycopeptides and Glycoproteins.- 8.4 Glycosilylation Engineering of Glycoproteins.-
8.5 Glycoprotein Analysis
9.1 Azaglycomimetics: Synthesis and Chemical Biology.- 9.2 Carbasugars: Synthesis and Functions.-
9.3 Sulfur Containing Glycomimetics.- 9.4 C-Glycosyl Analogs of Oligosaccharides and Glycosyl Amino Acids.
- 9.5 Non-Sugar Glycomimetics
10 Key Technologies and Tools for Functional Glycobiology.
10.1 Introduction.- 10.2 Microarrays.- 10.3 Chemical Probes and Monitoring.-
10.4 Glycomics and Mass Spectrometry.- 10.5 Bioinformatical Tools.
11 Biosynthesis and Degradation.
11.1 Introduction.- 11.2 Biosynthesis and Degradation
of Monosaccharides.- 11.3 Biosynthesis of Oligosaccharides and Polysaccharides.-11.4
Degradation of Oligosaccharides and Polysaccharides
12.1 Novel Approaches for Glycodrug Discovery.-
12.2 Biomedicine of Monosaccharides.- 12.3 Mammalian Carbohydrate-Lectin Interactions.-
12.4 Multivalency in Protein-Carbohydrate Recognition.- 12.5 Synthesis of Heparin-Fragments.-
12.6 Biomedicine of Glycolipids and Glycosphingolipids.- 12.7 Biomedicine of Enkephalin-Derived
Glycopeptide Analgesics.- 12.8 Antitumor and Antimicrobial Glycoconjugates.- 12.9 Biomedicine
of Glycosylated Natural Compounds.- 12.10 Mucin-based Vaccines.- 12.11 Polysaccharide-based Vaccines
: analytical methods
: biology, general
: cell biology