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Hydrolases in Organic Synthesis: Regio- and Stereoselective Biotransformations, 2nd Edition

Uwe Theo Bornscheuer, Romas Joseph Kazlauskas 
Wiley  November 2005  



Hardcover  368 pages  ISBN 9783527310296      £140.00
The second edition of this extremely successful and well-proven book reflects recent developments in the use of hydrolases for organic synthesis. The renowned authors have added a new chapter on protein sources and optimization of biocatalyst performance for organic synthesis, an expanded chapter about directed evolution and a new chapter covering catalytic promiscuity. Furthermore, the sections dealing with dynamic kinetic resolution and immobilization have been substantially updated. Also, new classes of hydrolases, such as haloalkane dehalogenases and organophosphorus hydrolases are now covered.

Thus, the 2nd edition covers an even broader field and provides an excellent overview of stereoselective reactions using hydrolases, such that researchers can solve their own synthetic problems. In all, the book contains over one thousand chemical structures and around 1,800 valuable references.

Contents

1 Introduction.

2 Designing Enantioselective Reactions.

  • 2.1 Kinetic Resolutions.
  • 2.2 Asymmetric Syntheses.

3 Choosing Reaction Media: Water and Organic Solvents.

  • 3.1 Hydrolysis in Water.
  • 3.2 Transesterifications and Condensations in Organic Solvents.
  • 3.3 Other Reaction Media.
  • 3.4 Immobilization.

4 Protein Sources and Optimization of Biocatalyst Performance.

  • 4.1 Accessing Biodiversity.
  • 4.2 Creating Improved Biocatalysts.
  • 4.3 Catalytic Promiscuity in Hydrolases.

5 Lipases and Esterases.

  • 5.1 Availability, Structures and Properties.
  • 5.2 Survey of Enantioselective Lipase-Catalyzed Reactions.
  • 5.3 Chemo-and Regioselective Lipase-Catalyzed Reactions.
  • 5.4 Reactions Catalyzed by Esterases.

6 Proteases and Amidases.

  • 6.1 Occurrence and Availability of Proteases and Amidases.
  • 6.2 General Features of Subtilisin, Chymotrypsin, and Other Proteases and Amidases.
  • 6.3 Structures of Proteases and Amidases.
  • 6.4 Survey of Enantioselective Protease-and Amidase-Catalyzed Reactions.

7 Phospholipases.

  • 7.1 Phospholipase A1.
  • 7.2 Phospholipase A2.
  • 7.3 Phospholipase C.
  • 7.4 Phospholipase D.

8 Epoxide Hydrolases.

  • 8.1 Introduction.
  • 8.2 Mammalian Epoxide Hydrolases.
  • 8.3 Microbial Epoxide Hydrolases.

9 Hydrolysis of Nitriles.

  • 9.1 Introduction.
  • 9.2 Mild Conditions.
  • 9.3 Regioselective Reactions of Dinitriles.
  • 9.4 Enantioselective Reactions.

10 Other Hydrolases.

  • 10.1 Glycosidases.
  • 10.2 Haloalcohol Dehalogenases.
  • 10.3 Phosphotriesterases.

Abbreviations.
References.
Index.

To find similar publications, click on a keyword below:
Wiley : biochemistry : biological conversion : chemistry : enzymology : synthesis, chemical

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