Mammalian Genomics

Edited by A Ruvinsky, J A Marshall Graves 
CABI  December 2004  

Hardback  624 pp  ISBN 9780851999104      £155.00
This book:
  • Brings together a diverse range of genomic studies relevant to mammals, including humans
  • Is written by leading international researchers working in different areas of mammalian genetics and genomics
  • Presents both classic studies and the latest research findings in gene mapping and related topics
Genomics has experienced a dramatic development during the last 15-20 years. Data from mammalian genomes such as the human, mouse and rat have already been published, while others such as the dog, cattle and chimpanzee will soon follow. This book summarizes the current knowledge of mammalian genomics and offers a comparative analysis of genomes known today. This analysis includes farm, companion and lab animals. Topics covered include structural and functional aspects of the mammalian genome, mechanisms of genomic changes at the molecular level, evolution of DNA sequences, comparative chromosome mapping and painting, genome databases, gene prediction and the use of genomic information to understand inherited diseases. Contributors include leading researchers from Europe, USA, Australia and Japan.

Readership: Researchers and academics in human and animal genetics, and animal breeding.


Part 1. Organization of the Mammalian Genome

Linkage mapping, C Moran and J W James, University of Sydney, Australia
Mapping genomes at the chromosome level, B P Chowdhary and T Raudsepp, Texas A&M University, USA
Mapping genomes at the molecular level, F Galibert, Universite de Rennes, France, and N E Cockett, Utah State Univeristy, USA
DNA sequence of the human and other mammalian genomes, D Vaiman, INSERM, France

Part 2. Expression of the Mammalian Genome
The transcriptome, A Verger and M Crossley, University of Sydney, Australia
The proteome, M B Datto and T A Haystead, Duke University, USA
The epigenome - epigenetic regulation of gene expression in mammalian species, E Whitelaw, University of Sydney, and D Garrick, John Radcliffe Hospital, Oxford, UK
Regulation of genome activity and genetic networks in mammals, V Van Buren, and M S H Ko, National Institute of Health, USA
Inducing alterations in the mammalian genome for investigating the function of genes, J L Guénet, Institut Pasteur, France

Part 3. Evolution of the Mammalian Genome
Mammalian genomes in context, M I Bellgard, Murdoch University, Australia, and T Gojobori, National Institute of Genetics, Japan
Elements and mechanisms of genome change, R J O€Neill, G C Ferreri and M J O€Neil, University of Connecticut, USA
DNA sequence evolution and phylogenetic footprinting, E T Dermitzakis, The Wellcome Trust Sanger Institute, Cambridge, UK, and A Reymond, University of Geneva Medical School, Switzerland
The evolution of the mammalian karyotype, F Pardo-Manuel de Villena, University of North Carolina at Chapel Hill, USA
Comparative gene mapping and chromosome painting in mammals and the reconstruction of the ancestral mammalian karyotype, O L Serov, Russian Academy of Sciences, Russia, B P Chowdhary, J E Womack, Texas A&M University, USA, and J A Marshall Graves, The Australian National University, Australia

Part 4. Genome Analysis and Bioinformatics
Bioinformatics: from computational analysis through to integrated systems, M I Bellgard
Genetic databases, V Brusic and J L Y Koh, Institute for Infocomm Research, Singapore
Gene predictions and annotations, R Guidó, Universitat Pompeu Fabra, Spain, and M Q Zhang, Cold Spring Harbor Laboratory, USA

Part 5. The Fruits of Mammalian Genomics
Genomic research and progress in understanding inherited disorders in humans and other mammals, D R Sargan, University of Cambridge, UK, and A I Agoulnik, Baylor College of Medicine, Houston, USA
Pharmacogenomics, W W Weber and J M Rae, University of Michigan School of Medicine, USA
Genome scanning for quantitative trait loci, B J Hayes, Agricultural University of Norway, Norway, B P Kinghorn, and A Ruvinsky, University of New England, Australia
Mammalian population genetics and genomics, L Chikhi, Université Paul Sabatier, France, and M Bruford, Cardiff University, UK

To find similar publications, click on a keyword below:
CABI : animal science : biochemistry : bioinformatics : biotechnology : evolution : genomics : sequencing

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