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Applied Electrospray Mass Spectrometry

Edited by Birendra N. Pramanik, A. K. Ganguly, Michael L. Gross 
Marcel Dekker  2002  



Hard Cover  448 pages, Illustrated  ISBN 9780824706180      £158.00

"...covers a broad range of the modern applications of ESI-MS...well-written and structured."
Journal of Analytical Atomic Spectrometry

Discusses current strategies to determine the structure and machanisms of numerous compound classics. Covers new chemical and elctrophoretic techniques for rapid sample preconcentration and separation.

This state-of-the-art reference/text summarizes the most recent breakthroughs in the theory and instrumentation of electrospray mass spectrometry in pharmaceutical and biomedical applications - providing practical examples for the characterization of peptides, proteins, and glycoproteins, as well as applications in proteomics, combinatorial chemistry, and drug characterization.

Discusses current strategies to determine the structure and mechanisms of numerous compound classes, including synthetic organic compounds, B-lactams, steroids, macrocyclic compounds, peptides, glycoproteins, oligosaccharides, proteins, lipids, and polymers!

Detailing the latest advances in proteomics, noncovalent complexes of ligands and proteins, nanoflow methods, and combinatorial chemistry, Applied Electrospray Mass Spectrometry covers:

  • new chemical and electrophoretic techniques for rapid sample preconcentration and separation
  • modern screening processes for proteins from libraries of compounds
  • sensitive ionization methods for large biomolecules
  • the profiling of metabolites in in vivo and in vitro matrices
  • protein folding and dynamics

With more than 1000 contemporary references, Applied Electrospray Mass Spectrometry is an invaluable reference for mass spectrometrists; analytical, medicinal, and protein chemists and biochemists; biotechnologists; enzymologists; molecular biologists; and pharmaceutical scientists; and an excellent text for upper-level undergraduate and graduate students in these disciplines.

Contents

Electrospray Ionization Mass Spectrometry: History, Theory, and Instrumentation
Robert B. Cody

Nanospray Electrospray Ionization Development: LC/MS, CE/MS Application
Tom R. Covey and Devanand Pinto

Characterization of Pharmaceuticals and Natural Products by Electrospray Ionization Mass Spectrometry
K. Ganguly, Birendra N. Pramanik, Guodong Chen, Petia A. Shipkova

Electrospray Mass Spectrometry Applications in Combinatorial Chemistry
Mike S. Lee

Electrospray Mass Spectrometry in Contemporary Drug Metabolism and Pharmacokinetics
Mark J. Cole, John S. Janiszewski, and Hassan G. Fouda

Electrospray Mass Spectrospray of Peptides and Proteins: Methodologies and Applications
Joseph A. Loo and Greg W. Kilby

Structural Analysis of Glycoproteins by Electrospray Ionization Mass Spectrometry
Anthony Tsarbopoulos, Ute Bahr, Birendra N. Pramanik, and Michael Karas

Advanced Mass Spectrometric Approaches for Rapid and Quantitative Proteomics
Richard D. Smith, Gordon A. Anderson, Thomas P. Conrads, Christophe Masselon, Mary S. Lipton, Ljiljana Pasa Toli, and Timothy D. Veenstra

Detection of Noncovalent Complexes by Electrospray Ionization Mass Spectrometry
K. Ganguly, Birendra N. Pramanik, Guodong Chen, and Anthony Tsarbopoulos

Application of Hydrogen Exchange and Electrospray Ionization Mass Spectrometry in Studies of Protein Structure and Dynamics
Yinsheng Wang and Michael L. Gross

Microelectrospray Analysis Combined with Microdialysis Sampling of Neuropeptides and Drugs
Per E. Andrén and Richard M. Caprioli
Index

To find similar publications, click on a keyword below:
Marcel Dekker : analytical methods : bioproducts : biotechnology : mass spectrometry : pharmaceuticals : protein engineering

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